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⚡ Same-Day Shipping·Order by 3 PM ET, It Ships Today🇺🇸 100% Domestic·Synthesized & Shipped in the USABuy 2+ Save 5%·Buy 3+ Save 10%·Buy 5+ Save 15%·Buy 10+ Save 50%Free US Shipping on Crypto, Zelle, Cash App & Venmo OrdersFastest Dispatch in Research Peptides·Same-Day TrackingThird-Party Lab Tested·COAs Available on RequestResearch Grade·≥ 99% Purity Standard

Ares Research^™

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SPADIN ANALOGUE · RESEARCH HUB

PE-22-28 Research Hub — Spadin Analogue & TREK-1 Studies

PE-22-28 is a synthetic heptapeptide analogue of spadin, widely cited in research literature as a selective TREK-1 potassium-channel blocker with downstream effects on monoaminergic signalling.

What this hub covers

Spadin-derived heptapeptide structure
TREK-1 (KCNK2) potassium-channel blockade
Downstream monoaminergic signalling in published models
Reconstitution and storage

PE-22-28 research articles

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Nootropic Research

PE-22-28 Research Overview

Spadin-derived hexapeptide TREK-1 antagonist studied for rapid-onset antidepressant effects, hippocampal neurogenesis, and BDNF upregulation.

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PE-22-28 research FAQ

What is PE-22-28?: PE-22-28 is a synthetic heptapeptide analogue of spadin, widely cited in research literature as a selective TREK-1 (KCNK2) potassium-channel blocker.

All content on this hub is provided strictly for laboratory research purposes. Compounds listed are not for human or veterinary consumption. See our research-use disclosure for full terms.