PT-141 (bremelanotide) is a synthetic cyclic heptapeptide that activates the melanocortin receptors, with relatively greater selectivity for MC3R and MC4R than non-selective analogs like MT-2.

How does PT-141 differ from MT-2?

PT-141 is derived as a linear metabolite of MT-2 and shows reduced activity at MC1R (pigmentation) and increased relative MC3R/MC4R selectivity, making it a distinct research tool for central melanocortin pathway studies.

What receptors does PT-141 act on?

PT-141 is an agonist at MC1R, MC3R, MC4R and MC5R, with the strongest research focus on MC3R/MC4R-mediated central pathways. See the PT-141 research overview for the receptor selectivity breakdown.

How is PT-141 stored?

Lyophilized PT-141 is stored at 2–8 °C protected from light. Reconstituted material should be refrigerated and used within the COA's documented window.

SELECTIVE MC3R/MC4R MELANOCORTIN AGONIST · RESEARCH HUB

PT-141 Research Hub — Bremelanotide Melanocortin Studies

PT-141 (bremelanotide) is a synthetic cyclic heptapeptide derived as a metabolite of Melanotan-II, with greater selectivity for the MC3R and MC4R melanocortin receptors. It is widely cited in central melanocortin pathway and behavioural-pharmacology research.

View PT-141 on the catalog Certificates of Analysis

What this hub covers

Cyclic heptapeptide structure and metabolite origin from MT-2
MC3R/MC4R-selective melanocortin agonism
Central melanocortin pathway literature
Comparisons to non-selective MT-2 and α-MSH
Reconstitution, storage and handling for research use

PT-141 research articles

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Comparison

PT-141 vs Kisspeptin-10 — Research Comparison (2026)

PT-141 vs kisspeptin-10 for sexual-response research: central melanocortin pathway vs upstream HPG-axis activation.

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Reconstitution

PT-141 Reconstitution & Storage — Research Guide (2026)

PT-141 reconstitution and storage guide: vial sizes, diluent volumes, U-100 syringe math, and stability windows for laboratory research.

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Safety Research

PT-141 (Bremelanotide) Safety Profile

PT-141 safety profile: blood pressure effects, nausea, hyperpigmentation considerations, and monitoring protocols.

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Wellness Research

PT-141 (Bremelanotide) Research Overview

PT-141 (Bremelanotide): MC4R mechanism, hypothalamic sexual motivation signalling, FDA approval context, and comparison to peripheral PDE5 inhibitors in sexual function research.

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Sexual Response Research

PT-141 Benefits and Side Effects: A Research Guide

Published benefits, side effects, and Melanotan II comparisons for PT-141 (bremelanotide) — the only FDA-approved peptide for sexual desire.

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Wellness Research

Melanocortin Research Overview

The melanocortin system consists of five receptor subtypes (MC1R–MC5R), endogenous peptide ligands derived from proopiomelanocortin (POMC), and two endogenous antagonists (Agouti protein and Agouti-related protein, AgRP). POMC is a large...

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Comparison

Melanotan 2 vs PT-141: Melanocortin Receptor Research

Compare Melanotan 2 (MT-2) and PT-141 (bremelanotide) — two melanocortin-receptor agonists — across receptor selectivity, pigmentation effects, and published research.

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Mechanism of Action

PT-141 (Bremelanotide) Mechanism of Action

Pharmacology of the cyclic heptapeptide PT-141 (bremelanotide): MC4R / MC3R agonism, central sexual response circuits, and distinction from PDE5-inhibitor mechanisms.

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PT-141 research FAQ

What is PT-141?: PT-141 (bremelanotide) is a synthetic cyclic heptapeptide that activates the melanocortin receptors, with relatively greater selectivity for MC3R and MC4R than non-selective analogs like MT-2.
How does PT-141 differ from MT-2?: PT-141 is derived as a linear metabolite of MT-2 and shows reduced activity at MC1R (pigmentation) and increased relative MC3R/MC4R selectivity, making it a distinct research tool for central melanocortin pathway studies.
What receptors does PT-141 act on?: PT-141 is an agonist at MC1R, MC3R, MC4R and MC5R, with the strongest research focus on MC3R/MC4R-mediated central pathways. See the PT-141 research overview for the receptor selectivity breakdown.
How is PT-141 stored?: Lyophilized PT-141 is stored at 2–8 °C protected from light. Reconstituted material should be refrigerated and used within the COA's documented window.

All content on this hub is provided strictly for laboratory research purposes. Compounds listed are not for human or veterinary consumption. See our research-use disclosure for full terms.