GHK-Cu
Endogenous copper-binding tripeptide studied across extracellular matrix and tissue-repair models.
Mechanism
GHK-Cu is the copper(II) complex of the glycyl-L-histidyl-L-lysine tripeptide. Research models study its modulation of extracellular matrix remodeling, antioxidant enzyme expression, and copper delivery to fibroblasts.
Discovery
Isolated from human plasma by Loren Pickart in 1973 as a factor influencing hepatocyte growth in albumin fractions. Its copper-binding activity was characterized soon after.
Research Status
Broad and mature research literature spanning dermal, follicular, and wound-healing research models. One of the best-characterized short peptides in cosmetic and matrix research.
Quality Notes
Correct copper:peptide stoichiometry (1:1) and absence of free copper are essential. Ares GHK-Cu is third-party tested with COA.
Related research
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