Tesamorelin
Stabilized GHRH analog studied in growth hormone axis and visceral adipose research.
Mechanism
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) with an N-terminal modification that resists dipeptidyl peptidase-4 degradation. Binds pituitary GHRH receptors and is studied for pulsatile GH release preserving physiological feedback.
Discovery
Developed in the 2000s as a stabilized 44-amino-acid GHRH analog. Received a defined regulatory indication in 2010 for HIV-associated lipodystrophy in clinical use.
Research Status
Well-characterized in the GH/IGF-1 axis research literature. Frequently used as a reference compound for GHRH-arm signaling studies.
Quality Notes
Correct 44-mer sequence with intact N-terminal modification is critical to receptor activity. Ares tesamorelin is third-party tested for identity and purity.
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