MOTS-c
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≥99% purity verified by independent HPLC and mass spectrometry (MS) through Janoshik Analytical. Intended for laboratory research use only; not for human consumption, diagnosis, or treatment. View transparency report Compliance PDFs
Documentation & standards
- How to Read a Peptide Certificate of Analysis (COA)
- Peptide Storage and Handling: Temperature, Light and Stability
- Research-Use-Only Compliance: What the Label Obligates
Mitochondrial-derived peptide studied in metabolic regulation research.
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Batch transparency
- Batch / lot
- Released with your order
- Testing lab
- Janoshik Analytical
- Purity (HPLC)
- ≥99% target spec
- Identity (MS)
- Available on request
- Report issued
- Available on request
- Full PDF report
- By request
Every request returns a reference number and a live status page. See all published batch records →
For laboratory research use only — not for human or veterinary use.
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Intended strictly for research and laboratory use only. Not for human consumption.
About MOTS-c
Third-party purity testing available upon request.
Research Classification
Storage Information
MOTS-c Purity & COA Verification
For laboratory research use only. Not for human consumption, diagnosis, or treatment.
MOTS-c — Compound Information & Scientific Literature
Reference data for laboratory personnel: molecular identity, storage and stability handling, our analytical testing panel, and peer-reviewed literature indexed on PubMed.
Molecular Profile
| Compound | MOTS-c |
|---|---|
| Molecule type | Mitochondrial-derived peptide (16 aa) |
| Class | Mitochondrial Peptide |
| Catalog category | Metabolic & Fat Loss Research |
| Physical format | Lyophilized vial |
Handling Reference
-20 °C, protected from light and moisture
24 months from date of manufacture in the sealed vial
2-8 °C (refrigerated), do not freeze after reconstitution
Stability studied out to approximately 28 days under continuous refrigeration
Analytical Testing Panel
Verified by Janoshik Analytical — full panel, every batch. Second independent lab confirmation is being added batch by batch.
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
Every MOTS-c lot passes all 8 stages before it is released. Expand a stage to see the method and why we run it.
- Method on the COARP-HPLC (UV 214 nm)Why Ares runs it
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
- Method on the COAQuantitative HPLC mass/concentration assayWhy Ares runs it
Confirms the vial actually contains the labeled amount — purity alone says nothing about how much material is in the vial.
- Method on the COAMass Spectrometry (ESI-MS)Why Ares runs it
Confirms the measured molecular mass matches the declared compound — the check that catches a mislabeled or substituted vial.
- Method on the COAICP-MSWhy Ares runs it
Screens for elemental contaminants carried over from synthesis, reagents, or packaging.
- Method on the COAMembrane filtration, USP <71> methodologyWhy Ares runs it
Checks the finished lyophilized vial for microbial growth after fill and closure.
- Method on the COALAL assay (kinetic chromogenic)Why Ares runs it
Measures bacterial endotoxin load, a contamination marker that purity testing alone will not reveal.
- Method on the COAIndependent batch review against release specificationWhy Ares runs it
Ties the analytical numbers back to the paperwork — the lot you receive is the lot on the certificate.
- Method on the COALC-MS/MS targeted screenWhy Ares runs it
A contamination check most research suppliers never run, and the reason we run it on every batch regardless of compound.
PASS reflects the batch release standard every lot must meet before it ships. Per-lot results are published on that lot's Certificate of Analysis.
Peer-Reviewed References
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
Zheng Y et al. · Frontiers in endocrinology, 2023 · PMID 36761202
View sourceThe mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C et al. · Cell metabolism, 2015 · PMID 25738459
View sourceMitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination
Yin Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024 · PMID 39321430
View sourceThe mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus
Yin Y et al. · Pharmacological research, 2022 · PMID 34798268
View sourceMOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
Mohtashami Z et al. · International journal of molecular sciences, 2022 · PMID 36233287
View source
References are listed for literature-identification purposes only. Ares Research is not affiliated with the authors, journals, or institutions cited.
This material is supplied for laboratory and research use only. It is not for human or veterinary use, and it is not a drug, food, or cosmetic. These statements have not been evaluated by the Food and Drug Administration. No information on this page is intended to diagnose, treat, cure, or prevent any condition.
Read the MOTS-c research
Research-only pharmacokinetic profile of MOTS-c: serum half-life, Tmax, route comparisons, clearance and bioavailability — curated from published preclinical and clinical PK literature.
Read article →MOTS-c vs NAD+ for mitochondrial research: AMPK signaling vs sirtuin cofactor supply, dosing routes and metabolic endpoints.
Read article →MOTS-c reconstitution and storage guide: vial sizes, diluent volumes, U-100 syringe math, and stability windows for laboratory research.
Read article →MOTS-c mitochondrial peptide safety profile: tolerability, metabolic monitoring, and exclusion criteria.
Read article →A mitochondria-derived peptide encoded within the 12S rRNA gene, studied for its role in metabolic regulation, insulin sensitivity, longevity signaling, and exercise adaptation in cellular and animal research models.
Read article →Published benefits, side effects, and mechanism review for MOTS-c — the mitochondrial-derived peptide that activates AMPK and is studied for insulin sensitivity, exercise capacity, and metabolic aging.
Read article →How Ares compares for MOTS-c
Independent, documentation-first breakdowns of the vendors researchers most often ask about for this compound. COA verification, US shipping, and sourcing transparency, side by side.
Frequently bought together
Curated complements for this compound — researchers most often pair it with these.
Research Use Disclaimer
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All testing documentation and COA data are provided for laboratory research use only and are not intended to support human consumption, diagnostic, or therapeutic use.
Independent Certificate of Analysis
Independently tested by In-House Verification. Verified and batch-tracked by Ares Research. Additional reports available upon request.
No fillers. No shortcuts. Only verified compounds.
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