TB-500
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≥99% purity verified by independent HPLC and mass spectrometry (MS) through Janoshik Analytical. Intended for laboratory research use only; not for human consumption, diagnosis, or treatment. View transparency report Compliance PDFs
Documentation & standards
- Third-Party Peptide Testing: HPLC, Mass Spec & What Each Proves
- Peptide Purity Verification: Turning a Claim Into Evidence
- How to Read a Peptide Certificate of Analysis (COA)
Synthetic peptide fragment used in advanced tissue and cellular research applications.
Supplied in an Ares dial-a-dose dispensing pen instead of a vial. Choose a prefilled pen, or a cartridge refill if you already own the Ares Precision Pen.
Mix and match any items — discount applies automatically at checkout.
Reminder email when it's time to reorder. No card on file. Cancel anytime from your account — or email support@aresresearchlab.com.
Curated research selection for tissue and regenerative research models.
Build the full stack →Batch transparency
- Batch / lot
- Released with your order
- Testing lab
- Janoshik Analytical
- Purity (HPLC)
- ≥99% target spec
- Identity (MS)
- Available on request
- Report issued
- Available on request
- Full PDF report
- By request
Every request returns a reference number and a live status page. See all published batch records →
For laboratory research use only — not for human or veterinary use.
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Create a Research Account to unlock full batch data, COAs, and priority releases.
Intended strictly for research and laboratory use only. Not for human consumption.
About TB-500
Third-party purity testing available upon request.
Research Classification
Storage Information
TB-500 Purity & COA Verification
For laboratory research use only. Not for human consumption, diagnosis, or treatment.
TB-500 — Compound Information & Scientific Literature
Reference data for laboratory personnel: molecular identity, storage and stability handling, our analytical testing panel, and peer-reviewed literature indexed on PubMed.
Molecular Profile
| Compound | TB-500 |
|---|---|
| Molecule type | Synthetic peptide fragment of thymosin beta-4 |
| Class | Thymosin Fragment |
| Catalog category | Recovery |
| Physical format | Lyophilized vial |
Handling Reference
-20 °C, protected from light and moisture
24 months from date of manufacture in the sealed vial
2-8 °C (refrigerated), do not freeze after reconstitution
Stability studied out to approximately 28 days under continuous refrigeration
Analytical Testing Panel
Verified by Janoshik Analytical — full panel, every batch. Second independent lab confirmation is being added batch by batch.
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
Every TB-500 lot passes all 8 stages before it is released. Expand a stage to see the method and why we run it.
- Method on the COARP-HPLC (UV 214 nm)Why Ares runs it
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
- Method on the COAQuantitative HPLC mass/concentration assayWhy Ares runs it
Confirms the vial actually contains the labeled amount — purity alone says nothing about how much material is in the vial.
- Method on the COAMass Spectrometry (ESI-MS)Why Ares runs it
Confirms the measured molecular mass matches the declared compound — the check that catches a mislabeled or substituted vial.
- Method on the COAICP-MSWhy Ares runs it
Screens for elemental contaminants carried over from synthesis, reagents, or packaging.
- Method on the COAMembrane filtration, USP <71> methodologyWhy Ares runs it
Checks the finished lyophilized vial for microbial growth after fill and closure.
- Method on the COALAL assay (kinetic chromogenic)Why Ares runs it
Measures bacterial endotoxin load, a contamination marker that purity testing alone will not reveal.
- Method on the COAIndependent batch review against release specificationWhy Ares runs it
Ties the analytical numbers back to the paperwork — the lot you receive is the lot on the certificate.
- Method on the COALC-MS/MS targeted screenWhy Ares runs it
A contamination check most research suppliers never run, and the reason we run it on every batch regardless of compound.
PASS reflects the batch release standard every lot must meet before it ships. Per-lot results are published on that lot's Certificate of Analysis.
Peer-Reviewed References
beta-Thymosins
Hannappel E · Annals of the New York Academy of Sciences, 2007 · PMID 17468232
View sourceThymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications
Goldstein AL et al. · Expert opinion on biological therapy, 2012 · PMID 22074294
View sourceSafety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Mendias CL et al. · Sports medicine (Auckland, N.Z.), 2026 · PMID 41966639
View sourceThymosin beta 4 and the eye: the journey from bench to bedside
Sosne G · Expert opinion on biological therapy, 2018 · PMID 30063853
View sourceThymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies
Bock-Marquette I et al. · International immunopharmacology, 2023 · PMID 36709593
View source
References are listed for literature-identification purposes only. Ares Research is not affiliated with the authors, journals, or institutions cited.
This material is supplied for laboratory and research use only. It is not for human or veterinary use, and it is not a drug, food, or cosmetic. These statements have not been evaluated by the Food and Drug Administration. No information on this page is intended to diagnose, treat, cure, or prevent any condition.
TB-500 research questions
+What is the documented purity of TB-500?
TB-500 (Thymosin Beta-4 fragment) is manufactured to ≥99% purity and verified by third-party HPLC-MS. A batch COA accompanies every lot.
+How does TB-500 compare to BPC-157 in research literature?
TB-500 is a synthetic fragment of Thymosin Beta-4 studied in actin-binding and tissue-repair pathways, while BPC-157 is a pentadecapeptide studied in nitric-oxide and growth-factor signaling pathways. See /compare/bpc-157-vs-tb-500 for a full comparison.
+What reconstitution volume is common for TB-500 in research?
Most published protocols reconstitute a 5 mg vial in 2–5 mL of bacteriostatic water. Use the reconstitution calculator to match your intended concentration per dose.
+Is TB-500 approved for clinical use?
No. TB-500 is supplied for in vitro and preclinical research only. It is not approved for human clinical use.
Read the TB-500 research
Research-only pharmacokinetic profile of TB-500: serum half-life, Tmax, route comparisons, clearance and bioavailability — curated from published preclinical and clinical PK literature.
Read article →Thymosin Beta-4: actin sequestration, tissue repair, angiogenesis, and cardiac protection research — a complete mechanistic and evidence overview.
Read article →Published benefits, side effects, and BPC-157 comparisons for TB-500 — the actin-sequestering Thymosin Beta-4 fragment used in tissue-repair research.
Read article →Compare BPC-157 and TB-500 (thymosin beta-4 fragment) — two leading tissue-repair research peptides — across mechanism, half-life, and published findings.
Read article →A literature-grounded reference for BPC-157's reported mechanisms, benefits across preclinical tissue-repair models, and documented safety profile — for research use only.
Read article →A comprehensive research primer on BPC-157 (Body Protection Compound-157) — a pentadecapeptide derived from human gastric juice. Covers origins, mechanism of action, tendon and gut healing research, angiogenesis, and CNS research findings.
Read article →How Ares compares for TB-500
Independent, documentation-first breakdowns of the vendors researchers most often ask about for this compound. COA verification, US shipping, and sourcing transparency, side by side.
Frequently bought together
Curated complements for this compound — researchers most often pair it with these.
Research Use Disclaimer
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All testing documentation and COA data are provided for laboratory research use only and are not intended to support human consumption, diagnostic, or therapeutic use.
Independent Certificate of Analysis
Independently tested by In-House Verification. Verified and batch-tracked by Ares Research. Additional reports available upon request.
No fillers. No shortcuts. Only verified compounds.
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TB-500 vs…
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