SS-31
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≥99% purity verified by independent HPLC and mass spectrometry (MS) through Janoshik Analytical. Intended for laboratory research use only; not for human consumption, diagnosis, or treatment. View transparency report Compliance PDFs
Documentation & standards
- How to Read a Peptide Certificate of Analysis (COA)
- Peptide Storage and Handling: Temperature, Light and Stability
- Research-Use-Only Compliance: What the Label Obligates
Mitochondria-targeted peptide used in bioenergetic research.
Supplied in an Ares dial-a-dose dispensing pen instead of a vial. Choose a prefilled pen, or a cartridge refill if you already own the Ares Precision Pen.
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Research selection for cellular longevity and mitochondrial research.
Build the full stack →Batch transparency
- Batch / lot
- Released with your order
- Testing lab
- Janoshik Analytical
- Purity (HPLC)
- ≥99% target spec
- Identity (MS)
- Available on request
- Report issued
- Available on request
- Full PDF report
- By request
Every request returns a reference number and a live status page. See all published batch records →
For laboratory research use only — not for human or veterinary use.
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Create a Research Account to unlock full batch data, COAs, and priority releases.
Intended strictly for research and laboratory use only. Not for human consumption.
About SS-31
Third-party purity testing available upon request.
Research Classification
Storage Information
SS-31 Purity & COA Verification
For laboratory research use only. Not for human consumption, diagnosis, or treatment.
SS-31 — Compound Information & Scientific Literature
Reference data for laboratory personnel: molecular identity, storage and stability handling, our analytical testing panel, and peer-reviewed literature indexed on PubMed.
Molecular Profile
| Compound | SS-31 |
|---|---|
| Molecule type | Mitochondrial Peptide |
| Class | Mitochondrial Peptide |
| Catalog category | Wellness |
| Physical format | Lyophilized vial |
Handling Reference
-20 °C, protected from light and moisture
24 months from date of manufacture in the sealed vial
2-8 °C (refrigerated), do not freeze after reconstitution
Stability studied out to approximately 28 days under continuous refrigeration
Analytical Testing Panel
Verified by Janoshik Analytical — full panel, every batch. Second independent lab confirmation is being added batch by batch.
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
Every SS-31 lot passes all 8 stages before it is released. Expand a stage to see the method and why we run it.
- Method on the COARP-HPLC (UV 214 nm)Why Ares runs it
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
- Method on the COAQuantitative HPLC mass/concentration assayWhy Ares runs it
Confirms the vial actually contains the labeled amount — purity alone says nothing about how much material is in the vial.
- Method on the COAMass Spectrometry (ESI-MS)Why Ares runs it
Confirms the measured molecular mass matches the declared compound — the check that catches a mislabeled or substituted vial.
- Method on the COAICP-MSWhy Ares runs it
Screens for elemental contaminants carried over from synthesis, reagents, or packaging.
- Method on the COAMembrane filtration, USP <71> methodologyWhy Ares runs it
Checks the finished lyophilized vial for microbial growth after fill and closure.
- Method on the COALAL assay (kinetic chromogenic)Why Ares runs it
Measures bacterial endotoxin load, a contamination marker that purity testing alone will not reveal.
- Method on the COAIndependent batch review against release specificationWhy Ares runs it
Ties the analytical numbers back to the paperwork — the lot you receive is the lot on the certificate.
- Method on the COALC-MS/MS targeted screenWhy Ares runs it
A contamination check most research suppliers never run, and the reason we run it on every batch regardless of compound.
PASS reflects the batch release standard every lot must meet before it ships. Per-lot results are published on that lot's Certificate of Analysis.
Peer-Reviewed References
Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice
Zhao W et al. · Journal of neuroinflammation, 2019 · PMID 31747905
View sourceThe mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)
Pharaoh G et al. · GeroScience, 2023 · PMID 37462785
View sourceMitochondria-targeted antioxidant peptide SS-31 mediates neuroprotection in a rat experimental glaucoma model
Wu X et al. · Acta biochimica et biophysica Sinica, 2019 · PMID 30811524
View sourceElamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential
Tung C et al. · International journal of molecular sciences, 2025 · PMID 39940712
View sourceThe mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action
Mitchell W et al. · The Journal of biological chemistry, 2020 · PMID 32273339
View source
References are listed for literature-identification purposes only. Ares Research is not affiliated with the authors, journals, or institutions cited.
This material is supplied for laboratory and research use only. It is not for human or veterinary use, and it is not a drug, food, or cosmetic. These statements have not been evaluated by the Food and Drug Administration. No information on this page is intended to diagnose, treat, cure, or prevent any condition.
Read the SS-31 research
Epitalon vs SS-31 (elamipretide): pineal/telomerase research peptide vs mitochondria-targeted cardiolipin peptide.
Read article →SS-31 (D-Arg-Dmt-Lys-Phe-NH₂) belongs to a class of Szeto-Schiller (SS) peptides developed by Hazel Szeto and Peter Schiller at Weill Cornell Medical College. The compound's distinctive alternating aromatic-cationic structure enables its...
Read article →Published benefits, side effects, and trial review for SS-31 (Elamipretide) — the cardiolipin-binding mitochondria-targeted peptide with the largest clinical dataset in the mitochondrial-research literature.
Read article →Published benefits, side effects, and mechanism review for MOTS-c — the mitochondrial-derived peptide that activates AMPK and is studied for insulin sensitivity, exercise capacity, and metabolic aging.
Read article →How Ares compares for SS-31
Independent, documentation-first breakdowns of the vendors researchers most often ask about for this compound. COA verification, US shipping, and sourcing transparency, side by side.
Frequently bought together
Curated complements for this compound — researchers most often pair it with these.
Research Use Disclaimer
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All testing documentation and COA data are provided for laboratory research use only and are not intended to support human consumption, diagnostic, or therapeutic use.
Independent Certificate of Analysis
Independently tested by In-House Verification. Verified and batch-tracked by Ares Research. Additional reports available upon request.
No fillers. No shortcuts. Only verified compounds.
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