Semaglutide (GLP-1S)
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≥99% purity verified by independent HPLC and mass spectrometry (MS) through Janoshik Analytical. Intended for laboratory research use only; not for human consumption, diagnosis, or treatment. View transparency report Compliance PDFs
Documentation & standards
- How to Read a Peptide Certificate of Analysis (COA)
- Peptide Storage and Handling: Temperature, Light and Stability
- Research-Use-Only Compliance: What the Label Obligates
Semaglutide (GLP-1S) is a synthetic GLP-1 receptor agonist supplied as high-purity laboratory reference material for metabolic-signalling research.
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Batch transparency
- Batch / lot
- Released with your order
- Testing lab
- Janoshik Analytical
- Purity (HPLC)
- ≥99% target spec
- Identity (MS)
- Available on request
- Report issued
- Available on request
- Full PDF report
- By request
Every request returns a reference number and a live status page. See all published batch records →
For laboratory research use only — not for human or veterinary use.
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Intended strictly for research and laboratory use only. Not for human consumption.
Semaglutide (GLP-1S) — GLP-1 Research Compound
Semaglutide, supplied by Ares Research as GLP-1S, is a synthetic GLP-1 receptor agonist studied in controlled metabolic-regulation and receptor-signalling research. Each batch is produced as high-purity laboratory reference material.
GLP-1S (semaglutide) is the single-agonist reference point in the Ares metabolic research sequence, followed by dual-agonist tirzepatide (GLP-2T) and triple-agonist retatrutide (GLP-3RT). Published studies have evaluated metabolic-regulation and body-weight endpoints under controlled research conditions.
Third-party purity testing available upon request.
Key Features
- High-purity research-grade compound
- Consistent batch quality
- Precision-formulated for laboratory research
- Manufactured under strict quality control
Semaglutide (GLP-1S) Research Applications
- GLP-1 receptor signalling research
- Metabolic-regulation endpoint studies
- Single-, dual- and triple-agonist comparison models
Research Classification
Storage Information
Semaglutide (GLP-1S) Purity & COA Verification
For laboratory research use only. Not for human consumption, diagnosis, or treatment.
What is semaglutide (GLP-1S)?
Semaglutide — supplied by Ares Research as GLP-1S — is a synthetic glucagon-like peptide-1 receptor agonist used as reference material in controlled metabolic-signalling research. Its defining profile is single-receptor GLP-1 agonism.
In the progression of incretin research, semaglutide represents the established single-agonist reference point, followed by dual-agonist tirzepatide (GLP-2T) and investigational triple-agonist retatrutide (GLP-3RT). These are distinct molecules studied separately because each engages a different receptor combination.
Published semaglutide research has examined metabolic regulation and body-weight endpoints under controlled study conditions. Those observations describe research measurements only and do not establish suitability or an expected outcome for any person. GLP-1S is supplied exclusively as laboratory research material.
Semaglutide (GLP-1S) product specifications
| Compound | Semaglutide (research designation GLP-1S) |
|---|---|
| Class | Synthetic peptide — GLP-1 receptor agonist |
| Purity standard | ≥99% by HPLC, with identity confirmed by mass spectrometry |
| Physical form | Lyophilised powder in a sealed glass vial |
| Available vial sizes | 5mg, 10mg, 15mg, 20mg and 30mg |
| Storage | Refrigerated and protected from light and moisture |
| Testing | Third-party Certificate of Analysis with batch-linked purity and identity data |
| Origin | Synthesised and shipped domestically (USA) |
| Intended use | Laboratory research use only — not for human or veterinary use |
Semaglutide COA and third-party verification
Every GLP-1S batch is independently tested before release. HPLC measures purity and mass spectrometry confirms molecular identity. The third-party report is tied to the vial batch number, allowing researchers to review the source result rather than relying on a general purity claim.
Testing documentation is supplied for laboratory research use only and does not support human, veterinary, diagnostic or therapeutic use.
Semaglutide research questions
+What is semaglutide (GLP-1S)?
Semaglutide, supplied by Ares Research as GLP-1S, is a synthetic GLP-1 receptor agonist used as laboratory reference material in metabolic-signalling research. It is supplied strictly for research use and is not for human or veterinary use.
+What does the GLP-1S name mean?
GLP-1S is the Ares Research SKU for semaglutide. The S identifies the single-agonist GLP-1 research material, distinguishing it from dual-agonist GLP-2T (tirzepatide) and triple-agonist GLP-3RT (retatrutide).
+How does semaglutide differ from tirzepatide and retatrutide?
Semaglutide is a single GLP-1 receptor agonist. Tirzepatide combines GIP and GLP-1 receptor activity, while retatrutide is studied for GIP, GLP-1 and glucagon receptor activity. Published research compares metabolic-regulation and body-weight endpoints across these distinct receptor profiles.
+How is GLP-1S (semaglutide) tested?
Each GLP-1S batch undergoes independent analytical testing. HPLC measures purity, mass spectrometry confirms molecular identity, and supporting panels document additional quality checks where available.
+Where can I find the semaglutide COA and purity result?
The batch-linked Certificate of Analysis can be checked through the Ares Research COA lookup. Published purity results and testing methodology are also available on the transparency page.
+How is Semaglutide (GLP-1S) research material shipped?
GLP-1S is shipped from the United States with tracked delivery. Every vial is supplied exclusively as laboratory research material.
+How should sealed GLP-1S research material be stored?
Keep the sealed lyophilised vial refrigerated, protected from light and moisture, and follow the batch handling documentation supplied with the research material.
Semaglutide (GLP-1S) — Compound Information & Scientific Literature
Reference data for laboratory personnel: molecular identity, storage and stability handling, our analytical testing panel, and peer-reviewed literature indexed on PubMed.
Molecular Profile
| Compound | Semaglutide (GLP-1S) |
|---|---|
| Molecule type | GLP-1 Receptor Agonist |
| Class | GLP-1 Receptor Agonist |
| Catalog category | Metabolic Research |
| Physical format | Lyophilized vial |
Handling Reference
-20 °C, protected from light and moisture
24 months from date of manufacture in the sealed vial
2-8 °C (refrigerated), do not freeze after reconstitution
Stability studied out to approximately 28 days under continuous refrigeration
Analytical Testing Panel
Verified by Janoshik Analytical — full panel, every batch. Second independent lab confirmation is being added batch by batch.
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
Every Semaglutide (GLP-1S) lot passes all 8 stages before it is released. Expand a stage to see the method and why we run it.
- Method on the COARP-HPLC (UV 214 nm)Why Ares runs it
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
- Method on the COAQuantitative HPLC mass/concentration assayWhy Ares runs it
Confirms the vial actually contains the labeled amount — purity alone says nothing about how much material is in the vial.
- Method on the COAMass Spectrometry (ESI-MS)Why Ares runs it
Confirms the measured molecular mass matches the declared compound — the check that catches a mislabeled or substituted vial.
- Method on the COAICP-MSWhy Ares runs it
Screens for elemental contaminants carried over from synthesis, reagents, or packaging.
- Method on the COAMembrane filtration, USP <71> methodologyWhy Ares runs it
Checks the finished lyophilized vial for microbial growth after fill and closure.
- Method on the COALAL assay (kinetic chromogenic)Why Ares runs it
Measures bacterial endotoxin load, a contamination marker that purity testing alone will not reveal.
- Method on the COAIndependent batch review against release specificationWhy Ares runs it
Ties the analytical numbers back to the paperwork — the lot you receive is the lot on the certificate.
- Method on the COALC-MS/MS targeted screenWhy Ares runs it
A contamination check most research suppliers never run, and the reason we run it on every batch regardless of compound.
PASS reflects the batch release standard every lot must meet before it ships. Per-lot results are published on that lot's Certificate of Analysis.
Peer-Reviewed References
GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art
Nauck MA et al. · Molecular metabolism, 2021 · PMID 33068776
View sourceDiscovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide
Lau J et al. · Journal of medicinal chemistry, 2015 · PMID 26308095
View sourceTirzepatide as Compared with Semaglutide for the Treatment of Obesity
Aronne LJ et al. · The New England journal of medicine, 2025 · PMID 40353578
View sourcePharmacokinetics and Clinical Implications of Semaglutide: A New Glucagon-Like Peptide (GLP)-1 Receptor Agonist
Hall S et al. · Clinical pharmacokinetics, 2018 · PMID 29915923
View sourceGlucagon-like peptide-1 receptor agonist use in pregnancy: a review
Drummond RF et al. · American journal of obstetrics and gynecology, 2025 · PMID 39181497
View source
References are listed for literature-identification purposes only. Ares Research is not affiliated with the authors, journals, or institutions cited.
This material is supplied for laboratory and research use only. It is not for human or veterinary use, and it is not a drug, food, or cosmetic. These statements have not been evaluated by the Food and Drug Administration. No information on this page is intended to diagnose, treat, cure, or prevent any condition.
How Ares compares for GLP-1S
Independent, documentation-first breakdowns of the vendors researchers most often ask about for this compound. COA verification, US shipping, and sourcing transparency, side by side.
Research Use Disclaimer
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All testing documentation and COA data are provided for laboratory research use only and are not intended to support human consumption, diagnostic, or therapeutic use.
Independent Certificate of Analysis
Independently tested by Janoshik Analytical. Verified and batch-tracked by Ares Research. Additional reports available upon request.
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