CJC-1295 (No-DAC)
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≥99% purity verified by independent HPLC and mass spectrometry (MS) through Janoshik Analytical. Intended for laboratory research use only; not for human consumption, diagnosis, or treatment. View transparency report Compliance PDFs
Documentation & standards
- Peptide Purity Verification: Turning a Claim Into Evidence
- How to Read a Peptide Certificate of Analysis (COA)
- Peptide Storage and Handling: Temperature, Light and Stability
Synthetic GHRH analog without DAC, studied in growth hormone signaling research.
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Batch transparency
- Batch / lot
- Released with your order
- Testing lab
- Janoshik Analytical
- Purity (HPLC)
- ≥99% target spec
- Identity (MS)
- Available on request
- Report issued
- Available on request
- Full PDF report
- By request
Every request returns a reference number and a live status page. See all published batch records →
For laboratory research use only — not for human or veterinary use.
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Intended strictly for research and laboratory use only. Not for human consumption.
About CJC-1295 (No-DAC)
Third-party purity testing available upon request.
Research Classification
Storage Information
CJC-1295 (No-DAC) Purity & COA Verification
For laboratory research use only. Not for human consumption, diagnosis, or treatment.
CJC-1295 COA and third-party testing
Every batch is independently analysed before release. HPLC measures purity against a ≥99% standard, mass spectrometry confirms molecular identity, and the published panel records heavy-metals, endotoxin and sterility screening where applicable. The COA is tied to the batch number printed on the vial, so the result can be verified at source rather than taken from a summary claim.
Testing documentation is supplied for laboratory research use only and does not support human, veterinary, diagnostic or therapeutic use.
What is CJC-1295 (No-DAC)?
CJC-1295 is a synthetic analog of growth-hormone-releasing hormone (GHRH) — a modified GRF (1-29) fragment produced by solid-phase synthesis. The No-DAC form omits the Drug Affinity Complex, so it clears quickly and is used in laboratory models where a short-acting GHRH-receptor input is required.
Published CJC-1295 research has characterised GHRH-receptor binding, the growth-hormone release signalling measured in study models, and IGF-1 marker readouts. These describe measurements recorded in research settings only; they do not establish an effect, benefit or suitability for any person, and nothing here constitutes medical, dosing or therapeutic guidance.
CJC-1295 DAC vs No-DAC
The only structural difference between the two forms is the Drug Affinity Complex (DAC). The DAC-modified peptide binds serum albumin, so it persists far longer in circulation in study models and produces a slow, sustained signalling profile. The No-DAC peptide has no such anchor and clears rapidly, producing a short, pulse-like profile in the same models.
That single distinction is why research designs choose one over the other: sustained-exposure work selects the DAC form, while designs modelling discrete pulses select No-DAC. Both are supplied as separate, individually tested research materials.
CJC-1295 (No-DAC) product specifications
| Compound | CJC-1295 without DAC (modified GRF 1-29) |
|---|---|
| Class | Growth-hormone-releasing hormone (GHRH) analog |
| Purity standard | ≥99% (HPLC, with identity confirmed by mass spectrometry) |
| Physical form | Lyophilised powder in a sealed glass vial |
| Available vial sizes | 2mg, 5mg and 10mg |
| Storage | Refrigerated and protected from light; batch handling documentation included |
| Testing | Third-party COA covering identity, purity, heavy metals, endotoxins and sterility |
| Origin | Synthesised and shipped domestically (USA) |
| Intended use | Laboratory research use only — not for human or veterinary use |
CJC-1295 research questions
+What is CJC-1295 (No-DAC)?
CJC-1295 (No-DAC) is a synthetic analog of growth-hormone-releasing hormone — a modified GRF (1-29) fragment produced by solid-phase peptide synthesis. Without the Drug Affinity Complex (DAC) modification it circulates only briefly, which is why laboratories use it when a short-acting GHRH-receptor reference material is required. It is supplied strictly as analytical research material.
+What is the difference between CJC-1295 with DAC and without DAC?
The distinction is the Drug Affinity Complex. The DAC form carries a modification that binds serum albumin and extends how long the peptide persists in circulation in study models, producing a slow, sustained signalling profile. The No-DAC form lacks that modification and clears rapidly, producing a short pulse-like profile in the same models. Ares Research supplies both as separate research materials so a study can select the pharmacokinetic profile it needs.
+What has published CJC-1295 research examined?
Published work has characterised binding at the GHRH receptor, the resulting growth-hormone release signalling observed in laboratory models, IGF-1 marker measurement, and the pharmacokinetic contrast between the DAC and No-DAC forms. These describe measurements recorded in research settings only and do not establish any effect, benefit or suitability for any person.
+Is a CJC-1295 COA available for each batch?
Yes. Every CJC-1295 batch is independently analysed before release and the COA is tied to the batch number printed on the vial, so the result can be verified at source rather than taken from a summary claim. Batch reports can be looked up on the COA page.
+What purity standard applies to this material?
Purity is measured by HPLC against a ≥99% standard, with molecular identity confirmed by mass spectrometry. The published panel also records heavy-metals, endotoxin and sterility screening where applicable.
+Is CJC-1295 suitable as a laboratory reference material?
It is supplied in the format laboratories generally require when qualifying a peptide as a comparison or reference material: lyophilised powder in a sealed vial, batch-linked third-party documentation, and recorded handling conditions. Suitability for any specific method remains the qualifying laboratory's determination.
+How is CJC-1295 shipped and stored?
Vials ship domestically from the USA in protective packaging. Material should be kept refrigerated and protected from light; batch handling documentation is included with each order. Research use only — not for human or veterinary use.
CJC-1295 (No-DAC) — Compound Information & Scientific Literature
Reference data for laboratory personnel: molecular identity, storage and stability handling, our analytical testing panel, and peer-reviewed literature indexed on PubMed.
Molecular Profile
| Compound | CJC-1295 (No-DAC) |
|---|---|
| Molecule type | GHRH Analog |
| Class | GHRH Analog |
| Catalog category | Growth Hormone |
| Physical format | Lyophilized vial |
Handling Reference
-20 °C, protected from light and moisture
24 months from date of manufacture in the sealed vial
2-8 °C (refrigerated), do not freeze after reconstitution
Stability studied out to approximately 28 days under continuous refrigeration
Analytical Testing Panel
Verified by Janoshik Analytical — full panel, every batch. Second independent lab confirmation is being added batch by batch.
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
Every CJC-1295 (No-DAC) lot passes all 8 stages before it is released. Expand a stage to see the method and why we run it.
- Method on the COARP-HPLC (UV 214 nm)Why Ares runs it
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
- Method on the COAQuantitative HPLC mass/concentration assayWhy Ares runs it
Confirms the vial actually contains the labeled amount — purity alone says nothing about how much material is in the vial.
- Method on the COAMass Spectrometry (ESI-MS)Why Ares runs it
Confirms the measured molecular mass matches the declared compound — the check that catches a mislabeled or substituted vial.
- Method on the COAICP-MSWhy Ares runs it
Screens for elemental contaminants carried over from synthesis, reagents, or packaging.
- Method on the COAMembrane filtration, USP <71> methodologyWhy Ares runs it
Checks the finished lyophilized vial for microbial growth after fill and closure.
- Method on the COALAL assay (kinetic chromogenic)Why Ares runs it
Measures bacterial endotoxin load, a contamination marker that purity testing alone will not reveal.
- Method on the COAIndependent batch review against release specificationWhy Ares runs it
Ties the analytical numbers back to the paperwork — the lot you receive is the lot on the certificate.
- Method on the COALC-MS/MS targeted screenWhy Ares runs it
A contamination check most research suppliers never run, and the reason we run it on every batch regardless of compound.
PASS reflects the batch release standard every lot must meet before it ships. Per-lot results are published on that lot's Certificate of Analysis.
Peer-Reviewed References
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
Teichman SL et al. · The Journal of clinical endocrinology and metabolism, 2006 · PMID 16352683
View sourceActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects
Sackmann-Sala L et al. · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2009 · PMID 19386527
View sourceOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
Alba M et al. · American journal of physiology. Endocrinology and metabolism, 2006 · PMID 16822960
View sourcePulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog
Ionescu M et al. · The Journal of clinical endocrinology and metabolism, 2006 · PMID 17018654
View sourceAdvances in the detection of growth hormone releasing hormone synthetic analogs
Memdouh S et al. · Drug testing and analysis, 2021 · PMID 34665524
View source
References are listed for literature-identification purposes only. Ares Research is not affiliated with the authors, journals, or institutions cited.
This material is supplied for laboratory and research use only. It is not for human or veterinary use, and it is not a drug, food, or cosmetic. These statements have not been evaluated by the Food and Drug Administration. No information on this page is intended to diagnose, treat, cure, or prevent any condition.
CJC-1295 (No-DAC) research questions
+What purity is CJC-1295 (No DAC) supplied at?
Every batch is manufactured to ≥99% purity and verified by HPLC and mass spectrometry, with a public batch COA on the product page.
+What is the difference between CJC-1295 with and without DAC?
CJC-1295 without DAC (Mod GRF 1-29) has a short half-life measured in minutes and is studied for pulsed GH signaling; the DAC variant binds serum albumin and extends half-life to roughly 8 days. See /compare/cjc-1295-dac-vs-cjc-1295-no-dac.
+How is CJC-1295 (No DAC) reconstituted?
Reconstitute with bacteriostatic water added slowly against the vial wall. Swirl gently until fully dissolved; do not shake.
+Is CJC-1295 (No DAC) intended for human use?
No. It is supplied strictly for laboratory research use only.
Read the CJC-1295 (No-DAC) research
Research-only pharmacokinetic profile of CJC-1295: serum half-life, Tmax, route comparisons, clearance and bioavailability — curated from published preclinical and clinical PK literature.
Read article →Recombinant HGH vs CJC-1295/Ipamorelin stack: exogenous vs endogenous GH release, pulsatility, safety profile and cost.
Read article →A research-context comparison of CJC-1295 with and without the Drug Affinity Complex modification — pharmacokinetics, GH secretion patterns, and the implications for pulsatility.
Read article →Published benefits, side effects, and DAC vs no-DAC comparisons for CJC-1295 — the stabilized GHRH(1-29) analog with two distinct research profiles.
Read article →GHRH analog (CJC-1295) vs GHRP (Ipamorelin) — side-by-side research comparison of mechanism, half-life, and why the two are commonly studied together.
Read article →Side-by-side comparison of CJC-1295 and sermorelin — two GHRH-analog research peptides — covering mechanism, half-life, pulsatility, and published research data.
Read article →How Ares compares for CJC-1295 (No DAC)
Independent, documentation-first breakdowns of the vendors researchers most often ask about for this compound. COA verification, US shipping, and sourcing transparency, side by side.
Frequently bought together
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All testing documentation and COA data are provided for laboratory research use only and are not intended to support human consumption, diagnostic, or therapeutic use.
Independent Certificate of Analysis
Independently tested by Janoshik Analytical. Verified and batch-tracked by Ares Research. Additional reports available upon request.
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