Ipamorelin
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≥99% purity verified by independent HPLC and mass spectrometry (MS) through Janoshik Analytical. Intended for laboratory research use only; not for human consumption, diagnosis, or treatment. View transparency report Compliance PDFs
Documentation & standards
- Third-Party Peptide Testing: HPLC, Mass Spec & What Each Proves
- How to Read a Peptide Certificate of Analysis (COA)
- Peptide Storage and Handling: Temperature, Light and Stability
Selective peptide examined in growth hormone secretagogue research.
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Research selection for growth hormone signaling pathway research.
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- Batch / lot
- Released with your order
- Testing lab
- Janoshik Analytical
- Purity (HPLC)
- ≥99% target spec
- Identity (MS)
- Available on request
- Report issued
- Available on request
- Full PDF report
- By request
Every request returns a reference number and a live status page. See all published batch records →
For laboratory research use only — not for human or veterinary use.
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Intended strictly for research and laboratory use only. Not for human consumption.
About Ipamorelin
Third-party purity testing available upon request.
Research Classification
Storage Information
Ipamorelin Purity & COA Verification
For laboratory research use only. Not for human consumption, diagnosis, or treatment.
Ipamorelin COA and third-party testing
Every ipamorelin batch is independently analysed before release. HPLC measures purity against a ≥99% standard, mass spectrometry confirms molecular identity, and the published panel records heavy-metals, endotoxin and sterility screening where applicable. The ipamorelin COA is tied to the batch number printed on the vial, so the result can be verified at source rather than taken from a summary claim.
Testing documentation is supplied for laboratory research use only and does not support human, veterinary, diagnostic or therapeutic use.
What is ipamorelin?
Ipamorelin is a selective growth hormone secretagogue — a synthetic pentapeptide described in the literature as a high-affinity agonist at the growth hormone secretagogue receptor 1a (GHS-R1a), the receptor engaged by endogenous ghrelin. Its N-terminal aminoisobutyric acid residue is reported to resist DPP-IV cleavage.
The property that defines ipamorelin in published research is selectivity: comparison work reports growth-hormone release in study models without the measurable cortisol, prolactin or aldosterone movement recorded for less selective GHRPs such as GHRP-2, GHRP-6 and hexarelin. These describe measurements taken in research settings only; they do not establish an effect, benefit or suitability for any person, and nothing here constitutes medical, dosing or therapeutic guidance.
Because of that profile, ipamorelin is frequently used as a reference comparator in the secretagogue literature — against the non-peptide small molecule MK-677 (ibutamoren), against hexarelin, and alongside GHRH analogues such as CJC-1295, sermorelin and tesamorelin. Ares Research supplies it as analytical research material with batch-linked documentation.
Ipamorelin product specifications
| Compound | Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2) |
|---|---|
| Class | Growth hormone secretagogue — selective GHS-R1a (ghrelin receptor) agonist |
| Purity standard | ≥99% (HPLC, with identity confirmed by mass spectrometry) |
| Physical form | Lyophilised powder in a sealed glass vial |
| Available vial sizes | 5mg and 10mg |
| Storage | Refrigerated and protected from light; batch handling documentation included |
| Testing | Third-party COA covering identity, purity, heavy metals, endotoxins and sterility |
| Origin | Synthesised and shipped domestically (USA) |
| Intended use | Laboratory research use only — not for human or veterinary use |
Ipamorelin research questions
+What is ipamorelin?
Ipamorelin is a short synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) classified as a growth hormone secretagogue. In published laboratory work it acts as a selective agonist at the growth hormone secretagogue receptor 1a (GHS-R1a), the same receptor engaged by endogenous ghrelin. Ares Research supplies it strictly as analytical research material for laboratory use.
+Why is ipamorelin described as selective?
In the published literature ipamorelin's binding is largely confined to GHS-R1a, and comparison studies report little measurable cross-activation of cortisol-, prolactin- or aldosterone-associated pathways at growth-hormone-effective concentrations in the models tested. That selectivity is the property most often cited when it is used as a reference secretagogue. It describes measurements in research models only.
+Ipamorelin vs MK-677 (ibutamoren) — what is the research difference?
Both are described in the literature as growth hormone secretagogues acting at GHS-R1a, but they are structurally different classes: ipamorelin is an injectable-format peptide with a short plasma half-life reported near two hours, while MK-677 (ibutamoren) is a non-peptide small molecule with a much longer reported half-life studied for sustained receptor engagement. Comparisons in research settings usually focus on selectivity, molecular class and pharmacokinetic profile rather than outcomes.
+Ipamorelin vs hexarelin — what distinguishes them?
Hexarelin is a hexapeptide GHRP reported in the literature to engage corticotrope and lactotrope populations alongside GHS-R1a, producing measurable ACTH and prolactin changes in study models. Ipamorelin's D-2-Nal/D-Phe scaffold is described as restricting high-affinity binding more narrowly to GHS-R1a. Reviews often frame hexarelin as the higher-potency, lower-selectivity reference and ipamorelin as the selectivity benchmark.
+How is Ares Research ipamorelin tested?
Every batch is analysed by an independent laboratory before release. HPLC measures purity against a ≥99% standard, mass spectrometry confirms molecular identity, and the published panel records heavy-metals, endotoxin and sterility screening where applicable. Results are tied to the batch number printed on the vial.
+Where can I see the ipamorelin COA?
Enter the batch number printed on your vial into the batch COA lookup to pull the third-party certificate of analysis for that exact lot. Aggregate purity statistics and lab-partner information for all compounds are published on the transparency page.
+What vial sizes and format are available?
Ipamorelin is supplied as a lyophilised powder in a sealed glass vial, in 5mg and 10mg sizes, stored refrigerated and protected from light. Orders ship domestically from the USA with batch documentation.
+Is this material suitable for human use?
No. All Ares Research material, including ipamorelin, is sold for laboratory research use only. It is not a drug or supplement and is not intended for human or veterinary consumption, diagnosis or treatment. No dosing, protocol or therapeutic guidance is provided.
Ipamorelin — Compound Information & Scientific Literature
Reference data for laboratory personnel: molecular identity, storage and stability handling, our analytical testing panel, and peer-reviewed literature indexed on PubMed.
Molecular Profile
| Compound | Ipamorelin |
|---|---|
| Molecule type | Synthetic pentapeptide |
| Class | GH Secretagogue |
| Catalog category | Growth Hormone |
| Physical format | Lyophilized vial |
Handling Reference
-20 °C, protected from light and moisture
24 months from date of manufacture in the sealed vial
2-8 °C (refrigerated), do not freeze after reconstitution
Stability studied out to approximately 28 days under continuous refrigeration
Analytical Testing Panel
Verified by Janoshik Analytical — full panel, every batch. Second independent lab confirmation is being added batch by batch.
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
Every Ipamorelin lot passes all 8 stages before it is released. Expand a stage to see the method and why we run it.
- Method on the COARP-HPLC (UV 214 nm)Why Ares runs it
Quantifies the main peak against related-substance peaks, so the stated purity percentage is measured rather than assumed.
- Method on the COAQuantitative HPLC mass/concentration assayWhy Ares runs it
Confirms the vial actually contains the labeled amount — purity alone says nothing about how much material is in the vial.
- Method on the COAMass Spectrometry (ESI-MS)Why Ares runs it
Confirms the measured molecular mass matches the declared compound — the check that catches a mislabeled or substituted vial.
- Method on the COAICP-MSWhy Ares runs it
Screens for elemental contaminants carried over from synthesis, reagents, or packaging.
- Method on the COAMembrane filtration, USP <71> methodologyWhy Ares runs it
Checks the finished lyophilized vial for microbial growth after fill and closure.
- Method on the COALAL assay (kinetic chromogenic)Why Ares runs it
Measures bacterial endotoxin load, a contamination marker that purity testing alone will not reveal.
- Method on the COAIndependent batch review against release specificationWhy Ares runs it
Ties the analytical numbers back to the paperwork — the lot you receive is the lot on the certificate.
- Method on the COALC-MS/MS targeted screenWhy Ares runs it
A contamination check most research suppliers never run, and the reason we run it on every batch regardless of compound.
PASS reflects the batch release standard every lot must meet before it ships. Per-lot results are published on that lot's Certificate of Analysis.
Peer-Reviewed References
Ipamorelin, the first selective growth hormone secretagogue
Raun K et al. · European journal of endocrinology, 1998 · PMID 9849822
View sourceTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman OF et al. · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2026 · PMID 41490200
View sourceInjectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Mayfield CK et al. · The American journal of sports medicine, 2026 · PMID 41476424
View sourceSafety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Mendias CL et al. · Sports medicine (Auckland, N.Z.), 2026 · PMID 41966639
View sourceIpamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats
Johansen PB et al. · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 1999 · PMID 10373343
View source
References are listed for literature-identification purposes only. Ares Research is not affiliated with the authors, journals, or institutions cited.
This material is supplied for laboratory and research use only. It is not for human or veterinary use, and it is not a drug, food, or cosmetic. These statements have not been evaluated by the Food and Drug Administration. No information on this page is intended to diagnose, treat, cure, or prevent any condition.
Ipamorelin research questions
+What purity level is Ipamorelin supplied at?
Ipamorelin is manufactured to ≥99% purity, verified by third-party HPLC and mass spectrometry with COA per batch.
+How does Ipamorelin differ from CJC-1295 in research models?
Ipamorelin is a GHRP (growth hormone releasing peptide) that acts on the ghrelin receptor to induce pulses, while CJC-1295 is a GHRH analog that raises baseline GH signaling. See /compare/ipamorelin-vs-cjc-1295-no-dac for a mechanism-level comparison.
+What is a common reconstitution ratio for Ipamorelin?
A common ratio is 2 mL bacteriostatic water per 5 mg vial (yielding 2.5 mg/mL). Use /tools/reconstitution-calculator to match your protocol's target concentration.
+Is Ipamorelin for human use?
No. Ipamorelin is supplied for laboratory research use only and is not for human or veterinary consumption.
Read the Ipamorelin research
Research-only pharmacokinetic profile of Ipamorelin: serum half-life, Tmax, route comparisons, clearance and bioavailability — curated from published preclinical and clinical PK literature.
Read article →Ipamorelin (peptide GHRP) vs MK-677/ibutamoren (oral ghrelin mimetic): selectivity, route, half-life and IGF-1 effects.
Read article →Recombinant HGH vs CJC-1295/Ipamorelin stack: exogenous vs endogenous GH release, pulsatility, safety profile and cost.
Read article →Ipamorelin safety profile: selectivity advantages over GHRP-2/6, prolactin/cortisol neutrality, common events, and monitoring.
Read article →Ipamorelin: mechanism of action, receptor selectivity, GH pulse profile, and comparison to other GHRPs in research contexts.
Read article →Published benefits, side effects, and GHRP comparisons for ipamorelin — the most receptor-selective GHRP and standard partner for GHRH analogues.
Read article →How Ares compares for Ipamorelin
Independent, documentation-first breakdowns of the vendors researchers most often ask about for this compound. COA verification, US shipping, and sourcing transparency, side by side.
Frequently bought together
Curated complements for this compound — researchers most often pair it with these.
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All testing documentation and COA data are provided for laboratory research use only and are not intended to support human consumption, diagnostic, or therapeutic use.
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